An easy way to change to a different codec, is by using encode() or decode(). In your case, you want to convert to ASCII and ignore all symbols that are not supported. For example, the Swedish letter å is not an ASCII character:
>>>s = u'Good bye in Swedish is Hej d\xe5'
>>>s = s.encode('ascii',errors='ignore')
>>>print s
Good bye in Swedish is Hej d
Edit:
Python3: str -> bytes -> str
>>>"Hej då".encode("ascii", errors="ignore").decode()
'hej d'
Python2: unicode -> str -> unicode
>>> u"hej då".encode("ascii", errors="ignore").decode()
u'hej d'
Python2: str -> unicode -> str (decode and encode in reverse order)
>>> "hej d\xe5".decode("ascii", errors="ignore").encode()
'hej d'