In python 3.x all strings are sequences of Unicode characters. and doing the isinstance check for str (which means unicode string by default) should suffice.
isinstance(x, str)
With regards to python 2.x, Most people seem to be using an if statement that has two checks. one for str and one for unicode.
If you want to check if you have a 'string-like' object all with one statement though, you can do the following:
isinstance(x, basestring)