The first one will be implemented:
Collection.Where(x => x.Age == 10)
.Where(x => x.Name == "Fido") // applied to the result of the previous
.Where(x => x.Fat == true) // applied to the result of the previous
As opposed to the much simpler (and far fasterpresumably faster):
// all in one fell swoop
Collection.Where(x => x.Age == 10 && x.Name == "Fido" && x.Fat == true)