int.from_bytes is the best solution if you are at version >=3.2. The "struct.unpack" solution requires a string so it will not apply to arrays of bytes. Here is another solution:
def bytes2int( tb, order='big'):
if order == 'big': seq=[0,1,2,3]
elif order == 'little': seq=[3,2,1,0]
i = 0
for j in seq: i = (i<<8)+tb[j]
return i
hex( bytes2int( [0x87, 0x65, 0x43, 0x21])) returns '0x87654321'.
It handles big and little endianness and is easily modifiable for 8 bytes