You can use the AND or OR operators, depending on what you want the search to return.
SELECT title FROM pages WHERE my_col LIKE %$param1% AND another_col LIKE %$param2%;
Both clauses have to match for a record to be returned. Alternatively:
SELECT title FROM pages WHERE my_col LIKE %$param1% OR another_col LIKE %$param2%;
If either clause matches then the record will be returned.
For more about what you can do with MySQL SELECT queries, try the documentation.