The easiest way to send (simulate) KeyStrokes to any window is to use the SendKeys.Send method of .NET Framework.
Checkout this very intuitive MSDN article http://msdn.microsoft.com/en-us/library/system.windows.forms.sendkeys.aspx
Particularly for your case, if your browser window is in focus, sending F5 would just involve the following line of code:
SendKeys.Send("{F5}");