A small variation on Husky's idea that I use. Make a file called 'globals' (or whatever you like) and then define multiple classes in it, as such:
#globals.py
class dbinfo : # for database globals
username = 'abcd'
password = 'xyz'
class runtime :
debug = False
output = 'stdio'
Then, if you have two code files c1.py and c2.py, both can have at the top
import globals as gl
Now all code can access and set values, as such:
gl.runtime.debug = False
print(gl.dbinfo.username)
People forget classes exist, even if no object is ever instantiated that is a member of that class. And variables in a class that aren't preceded by 'self.' are shared across all instances of the class, even if there are none. Once 'debug' is changed by any code, all other code sees the change.
By importing it as gl, you can have multiple such files and variables that lets you access and set values across code files, functions, etc., but with no danger of namespace collision.
This lacks some of the clever error checking of other approaches, but is simple and easy to follow.