You can use "ComboBoxItem.PreviewMouseDown" event. So each time when mouse is down on some item this event will be fired.
To add this event in XAML use "ComboBox.ItemContainerStyle" like in next example:
<ComboBox x:Name="MyBox"
ItemsSource="{Binding MyList}"
SelectedValue="{Binding MyItem, Mode=OneWayToSource}" >
<ComboBox.ItemContainerStyle>
<Style>
<EventSetter Event="ComboBoxItem.PreviewMouseDown"
Handler="cmbItem_PreviewMouseDown"/>
</Style>
</ComboBox.ItemContainerStyle>
</ComboBox>
and handle it as usual
void cmbItem_PreviewMouseDown(object sender, MouseButtonEventArgs e)
{
//...do your item selection code here...
}
Thanks to MSDN