When you access a OneToOneField you get the value of the field you queried. In this example a book model's 'title' field is a OneToOneField:
>>> from mysite.books.models import Book
>>> b = Book.objects.get(id=50)
>>> b.title
u'The Django Book'
When you access a ForeignKey you get the related model object, which you can then preform further queries against. In this example the same book model's 'publisher' field is a ForeignKey (correlating to the Publisher class model definition):
>>> b = Book.objects.get(id=50)
>>> b.publisher
<Publisher: Apress Publishing>
>>> b.publisher.website
u'http://www.apress.com/'
With ForeignKey fields queries work the other way too, but they're slightly different due to the non-symmetrical nature of the relationship.
>>> p = Publisher.objects.get(name='Apress Publishing')
>>> p.book_set.all()
[<Book: The Django Book>, <Book: Dive Into Python>, ...]
Behind the scenes, book_set is just a QuerySet and can be filtered and sliced like any other QuerySet. The attribute name book_set is generated by appending the lower case model name to _set.