First off, in order to have any image "resize" to fit a picturebox, you can set the PictureBox.SizeMode = PictureBoxSizeMode.StretchImage
If you want to do clipping of the image beforehand (i.e. cut off sides or top and bottom), then you need to clearly define what behavior you want (start at top, fill the height of the pciturebox and crop the rest, or start at the bottom, fill the height of the picturebox to the top, etc), and it should be fairly simple to use the Height / Width properties of both the picturebox and the image to clip the image and get the effect you are looking for.