You need to define a single locale that you will use for the data stored in the database, the invariant culture is there for exactly this purpose.
When you display convert to the native type and then format for the user's culture.
E.g. to display:
string fromDb = "123.56";
string display = double.Parse(fromDb, CultureInfo.InvariantCulture).ToString(userCulture);
to store:
string fromUser = "132,56";
double value;
// Probably want to use a more specific NumberStyles selection here.
if (!double.TryParse(fromUser, NumberStyles.Any, userCulture, out value)) {
// Error...
}
string forDB = value.ToString(CultureInfo.InvariantCulture);
PS. It, almost, goes without saying that using a column with a datatype that matches the data would be even better (but sometimes legacy applies).