You could walk up through the parents, noting their position within their parent, until you arrive at the Form.
Edit: Something like (untested):
public Point GetPositionInForm(Control ctrl)
{
Point p = ctrl.Location;
Control parent = ctrl.Parent;
while (! (parent is Form))
{
p.Offset(parent.Location.X, parent.Location.Y);
parent = parent.Parent;
}
return p;
}