[python] List vs tuple, when to use each?

But if I am the one who designs the API and gets to choose the data types, then what are the guidelines?

For input parameters it's best to accept the most generic interface that does what you need. It is seldom just a tuple or list - more often it's sequence, sliceable or even iterable. Python's duck typing usually gets it for free, unless you explicitly check input types. Don't do that unless absolutely unavoidable.

For the data that you produce (output parameters) just return what's most convenient for you, e.g. return whatever datatype you keep or whatever your helper function returns.

One thing to keep in mind is to avoid returning a list (or any other mutable) that's part of your state, e.g.

class ThingsKeeper
    def __init__(self):
        self.__things = []

    def things(self):
        return self.__things  #outside objects can now modify your state

    def safer(self):
        return self.__things[:]  #it's copy-on-write, shouldn't hurt performance

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