The given answer will throw an error if used in Microsoft Excel 14.0 Object Library. Object does not contain a definition for get_range. Instead use
int countRows = xlWorkSheetData.UsedRange.Rows.Count;
int countColumns = xlWorkSheetData.UsedRange.Columns.Count;
object[,] data = xlWorkSheetData.Range[xlWorkSheetData.Cells[1, 1], xlWorkSheetData.Cells[countRows, countColumns]].Cells.Value2;