If you're just looking at values of cells you can store the values in an array of variant type. It seems that getting the value of an element in an array can be much faster than interacting with Excel, so you can see some difference in performance using an array of all cell values compared to repeatedly getting single cells.
Dim ValArray as Variant
ValArray = Range("A1:IV" & Rows.Count).Value
Then you can get a cell value just by checking ValArray( row , column )