In addition to other people's answers of readability, maintainability, shorter code and therefore fewer bugs, and being much easier, I'll add an additional reason:
program speed.
Yes, in assembly you can hand tune your code to make use of every last cycle and make it as fast as is physically possible. However who has the time? If you write a not-completely-stupid C program, the compiler will do a really good job of optimizing for you. Probably making at least 95% of the optimizations you'd do by hand, without you having to worry about keeping track of any of it. There's definitely a 90/10 kind of rule here, where that last 5% of optimizations will end up taking up 95% of your time. So why bother?