I would get the part before and after what you want to replace and put them either side.
Like:
var str = 'asd-0.testing';
var regex = /(asd-)\d(\.\w+)/;
var matches = str.match(regex);
var result = matches[1] + "1" + matches[2];
// With ES6:
var result = `${matches[1]}1${matches[2]}`;