This is what I have done in order to get the column "first_name" fill the space when all the columns cannot do it.
When the grid go to small the column "first_name" gets almost invisible (very thin) so I can set the DataGridViewAutoSizeColumnMode to AllCells as the others visible columns. For performance issues it´s important to set them to None before data binding it and set back to AllCell in the DataBindingComplete event handler of the grid. Hope it helps!
private void dataGridView1_Resize(object sender, EventArgs e)
{
int ColumnsWidth = 0;
foreach(DataGridViewColumn col in dataGridView1.Columns)
{
if (col.Visible) ColumnsWidth += col.Width;
}
if (ColumnsWidth <dataGridView1.Width)
{
dataGridView1.Columns["first_name"].AutoSizeMode = DataGridViewAutoSizeColumnMode.Fill;
}
else if (dataGridView1.Columns["first_name"].Width < 10) dataGridView1.Columns["first_name"].AutoSizeMode = DataGridViewAutoSizeColumnMode.AllCells;
}