string[] TobeDistinct = {"Name","City","State"};
DataTable dtDistinct = GetDistinctRecords(DTwithDuplicate, TobeDistinct);
//Following function will return Distinct records for Name, City and State column.
public static DataTable GetDistinctRecords(DataTable dt, string[] Columns)
{
DataTable dtUniqRecords = new DataTable();
dtUniqRecords = dt.DefaultView.ToTable(true, Columns);
return dtUniqRecords;
}