You can choose any one of them http://www.python-excel.org/
I would recommended python xlrd library.
install it using
pip install xlrd
import using
import xlrd
to open a workbook
workbook = xlrd.open_workbook('your_file_name.xlsx')
open sheet by name
worksheet = workbook.sheet_by_name('Name of the Sheet')
open sheet by index
worksheet = workbook.sheet_by_index(0)
read cell value
worksheet.cell(0, 0).value