[python] Fastest way to check if a value exists in a list

It sounds like your application might gain advantage from the use of a Bloom Filter data structure.

In short, a bloom filter look-up can tell you very quickly if a value is DEFINITELY NOT present in a set. Otherwise, you can do a slower look-up to get the index of a value that POSSIBLY MIGHT BE in the list. So if your application tends to get the "not found" result much more often then the "found" result, you might see a speed up by adding a Bloom Filter.

For details, Wikipedia provides a good overview of how Bloom Filters work, and a web search for "python bloom filter library" will provide at least a couple useful implementations.

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