[c#] "The semaphore timeout period has expired" error for USB connection

I had this problem as well on two different Windows computers when communicating with a Arduino Leonardo. The reliable solution was:

  • Find the COM port in device manager and open the device properties.
  • Open the "Port Settings" tab, and click the advanced button.
  • There, uncheck the box "Use FIFO buffers (required 16550 compatible UART), and press OK.

Unfortunately, I don't know what this feature does, or how it affects this issue. After several PC restarts and a dozen device connection cycles, this is the only thing that reliably fixed the issue.

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