The top answers are correct. Please check them direct in MySQL CLI first. If this fixes the problem there, you may want to have it working in Python3 just pass it to the MySQLdb.connect
as parameter
self.connection = MySQLdb.connect(
host=host, user=settings_DB.db_config['USER'],
port=port, passwd=settings_DB.db_config['PASSWORD'],
db=settings_DB.db_config['NAME'],
local_infile=True)