Could you do something like this?
>>> import pandas as pd
>>> df = pd.DataFrame(columns=['col1', 'col2'])
>>> df = df.append(pd.Series(['a', 'b'], index=['col1','col2']), ignore_index=True)
>>> df = df.append(pd.Series(['d', 'e'], index=['col1','col2']), ignore_index=True)
>>> df
col1 col2
0 a b
1 d e
Does anyone have a more elegant solution?