A quick gotcha that I learned the hard way (basically spending 4 hours on Google), you can use PageMethods in your ASPX file to return JSON (with the [ScriptMethod()] marker) for a static method, however if you decide to move your static methods to an asmx file, it cannot be a static method.
Also, you need to tell the web service Content-Type: application/json in order to get JSON back from the call (I'm using jQuery and the 3 Mistakes To Avoid When Using jQuery article was very enlightening - its from the same website mentioned in another answer here).