[regex] RegEx to parse or validate Base64 data

Neither a ":" nor a "." will show up in valid Base64, so I think you can unambiguously throw away the http://www.stackoverflow.com line. In Perl, say, something like

my $sanitized_str = join q{}, grep {!/[^A-Za-z0-9+\/=]/} split /\n/, $str;

say decode_base64($sanitized_str);

might be what you want. It produces

This is simple ASCII Base64 for StackOverflow exmaple.

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