From the RFC 4648:
Base encoding of data is used in many situations to store or transfer data in environments that, perhaps for legacy reasons, are restricted to US-ASCII data.
So it depends on the purpose of usage of the encoded data if the data should be considered as dangerous.
But if you’re just looking for a regular expression to match Base64 encoded words, you can use the following:
^(?:[A-Za-z0-9+/]{4})*(?:[A-Za-z0-9+/]{2}==|[A-Za-z0-9+/]{3}=)?$