I will assume that the test is going to be used in a function, similar to user97370's answer. I don't like that answer because it pollutes the global namespace. One way to fix it is to use a class instead:
class InitMyVariable(object):
my_variable = None
def __call__(self):
if self.my_variable is None:
self.my_variable = ...
I don't like this, because it complicates the code and opens up questions such as, should this confirm to the Singleton programming pattern? Fortunately, Python has allowed functions to have attributes for a while, which gives us this simple solution:
def InitMyVariable():
if InitMyVariable.my_variable is None:
InitMyVariable.my_variable = ...
InitMyVariable.my_variable = None