Playing devil's advocate a little bit:
You should check the DjangoCon 2008 Keynote, delivered by Cal Henderson, titled "Why I hate Django" where he pretty much goes over everything Django is missing that you might want to do in a high traffic website. At the end of the day you have to take this all with an open mind because it is perfectly possible to write Django apps that scale, but I thought it was a good presentation and relevant to your question.