As you said, the issue here is not iframe content caching, but iframe url caching.
As of September 2018, it seems the issue still occurs in Chrome but not in Firefox.
I've tried many things (adding a changing GET parameter, clearing the iframe url in onbeforeunload, detecting a "reload from cache" using a cookie, setting up various response headers) and here are the only two solutions that worked from me:
1- Easy way: create your iframe dynamically from javascript
For example:
const iframe = document.createElement('iframe')
iframe.id = ...
...
iframe.src = myIFrameUrl
document.body.appendChild(iframe)
2- Convoluted way
Server-side, as explained here, disable content caching for the content you serve for the iframe OR for the parent page (either will do).
AND
Set the iframe url from javascript with an additional changing search param, like this:
const url = myIFrameUrl + '?timestamp=' + new Date().getTime()
document.getElementById('my-iframe-id').src = url
(simplified version, beware of other search params)