You can certainly #define a macro as shown below. The compiler will replace "IMAGE_SEGMENT" with its value before compilation. While you will achieve defining a global lookup for your array, it is not the same as a global variable. When the macro is expanded, it works just like inline code and so a new image is created each time. So if you are careful in where you use the macro, then you would have effectively achieved creating a global variable.
#define IMAGE_SEGMENT [[NSImage alloc] initWithContentsOfFile:@"/User/asd.jpg"];
Then use it where you need it as shown below. Each time the below code is executed, a new object is created with a new memory pointer.
imageSegment = IMAGE_SEGMENT