Or, alternatively, you could use Operator module. More detailed information is here Python docs
import operator
import numpy as np
import pandas as pd
np.random.seed(0)
df = pd.DataFrame(np.random.randn(5,3), columns=list('ABC'))
df.loc[operator.or_(df.C > 0.25, df.C < -0.25)]
A B C
0 1.764052 0.400157 0.978738
1 2.240893 1.867558 -0.977278
3 0.410599 0.144044 1.454274
4 0.761038 0.121675 0.4438