You can experiment with the native DB driver for Excel in language/platform of your choice. In Java world, you can try with http://code.google.com/p/sqlsheet/ which provides a JDBC driver for working with Excel sheets directly. Similarly, you can get drivers for the DB technology for other platforms.
However, I can guarantee that you will soon hit a wall with the number of features these wrapper libraries provide. Better way will be to use Apache HSSF/POI or similar level of library but it will need more coding effort.