I had the same issue with Xcode... black screen on launching apps, no debugging and clicking would lock up Xcode.
I finally found the problem... following the lead that the simulator could not connect to Xcode I took a look at my etc/hosts file and found that months ago to solve a different issue I had edited the host file to map localhost to my fixed IP instead of the default... my value:
10.0.1.17 localhost
This should work since that is my IP, but changing it back to the default IP fixed Xcode...
127.0.0.1 localhost
Hope this helps.