something like this
best to use a workbook variable to provide further control (if needed) of the opened workbook
updated to test that file name was an actual workbook - which also makes the initial check redundant, other than to message the user than the Textbox is blank
Dim strFile As String
Dim WB As Workbook
strFile = Trim(TextBox1.Value)
Dim DirFile As String
If Len(strFile) = 0 Then Exit Sub
DirFile = "C:\Documents and Settings\Administrator\Desktop\" & strFile
If Len(Dir(DirFile)) = 0 Then
MsgBox "File does not exist"
Else
On Error Resume Next
Set WB = Workbooks.Open(DirFile)
On Error GoTo 0
If WB Is Nothing Then MsgBox DirFile & " is invalid", vbCritical
End If