I was working on my Windows 10 machine and I'm not sure which package "broke" Spyder and Anaconda Navigator, but could have been either, or, or both Kivy-1.10.1 and moviepy-0.2.3.5 which gave me problems. I installed with either pip or conda. So of course I looked on this site to see what to do to fix. I found how pyqt was probably the issue. I uninstalled pyqt, kivy, and moviepy by using "pip uninstall ". I found where/or how they were installed by "pip list" and "conda list". After they were uninstalled I used "conda install - c anaconda pyqt" to reinstall pyqt. After installing pyqt I launched Spyder with no problems.