create a list of excludes, use fnmatch to skip the directory structure and do the process
excludes= ['a\*\b', 'c\d\e']
for root, directories, files in os.walk('Start_Folder'):
if not any(fnmatch.fnmatch(nf_root, pattern) for pattern in excludes):
for root, directories, files in os.walk(nf_root):
....
do the process
....
same as for 'includes':
if **any**(fnmatch.fnmatch(nf_root, pattern) for pattern in **includes**):