Slots are very useful for library calls to eliminate the "named method dispatch" when making function calls. This is mentioned in the SWIG documentation. For high performance libraries that want to reduce function overhead for commonly called functions using slots is much faster.
Now this may not be directly related to the OPs question. It is related more to building extensions than it does to using the slots syntax on an object. But it does help complete the picture for the usage of slots and some of the reasoning behind them.