Incorrect padding error is caused because sometimes, metadata is also present in the encoded string If your string looks something like: 'data:image/png;base64,...base 64 stuff....' then you need to remove the first part before decoding it.
Say if you have image base64 encoded string, then try below snippet..
from PIL import Image
from io import BytesIO
from base64 import b64decode
imagestr = 'data:image/png;base64,...base 64 stuff....'
im = Image.open(BytesIO(b64decode(imagestr.split(',')[1])))
im.save("image.png")