In the case you have different sample sizes, it may be difficult to compare the distributions with a single y-axis. For example:
import numpy as np
import matplotlib.pyplot as plt
#makes the data
y1 = np.random.normal(-2, 2, 1000)
y2 = np.random.normal(2, 2, 5000)
colors = ['b','g']
#plots the histogram
fig, ax1 = plt.subplots()
ax1.hist([y1,y2],color=colors)
ax1.set_xlim(-10,10)
ax1.set_ylabel("Count")
plt.tight_layout()
plt.show()
In this case, you can plot your two data sets on different axes. To do so, you can get your histogram data using matplotlib, clear the axis, and then re-plot it on two separate axes (shifting the bin edges so that they don't overlap):
#sets up the axis and gets histogram data
fig, ax1 = plt.subplots()
ax2 = ax1.twinx()
ax1.hist([y1, y2], color=colors)
n, bins, patches = ax1.hist([y1,y2])
ax1.cla() #clear the axis
#plots the histogram data
width = (bins[1] - bins[0]) * 0.4
bins_shifted = bins + width
ax1.bar(bins[:-1], n[0], width, align='edge', color=colors[0])
ax2.bar(bins_shifted[:-1], n[1], width, align='edge', color=colors[1])
#finishes the plot
ax1.set_ylabel("Count", color=colors[0])
ax2.set_ylabel("Count", color=colors[1])
ax1.tick_params('y', colors=colors[0])
ax2.tick_params('y', colors=colors[1])
plt.tight_layout()
plt.show()