You can avoid blocking execution by writing the plot to an array, then displaying the array in a different thread. Here is an example of generating and displaying plots simultaneously using pf.screen from pyformulas 0.2.8:
import pyformulas as pf
import matplotlib.pyplot as plt
import numpy as np
import time
fig = plt.figure()
canvas = np.zeros((480,640))
screen = pf.screen(canvas, 'Sinusoid')
start = time.time()
while True:
now = time.time() - start
x = np.linspace(now-2, now, 100)
y = np.sin(2*np.pi*x) + np.sin(3*np.pi*x)
plt.xlim(now-2,now+1)
plt.ylim(-3,3)
plt.plot(x, y, c='black')
# If we haven't already shown or saved the plot, then we need to draw the figure first...
fig.canvas.draw()
image = np.fromstring(fig.canvas.tostring_rgb(), dtype=np.uint8, sep='')
image = image.reshape(fig.canvas.get_width_height()[::-1] + (3,))
screen.update(image)
#screen.close()
Result:
Disclaimer: I'm the maintainer for pyformulas.
Reference: Matplotlib: save plot to numpy array