You can use triple-quoted strings. When they're not a docstring (the first thing in a class/function/module), they are ignored.
'''
This is a multiline
comment.
'''
(Make sure to indent the leading '''
appropriately to avoid an IndentationError
.)
Guido van Rossum (creator of Python) tweeted this as a "pro tip".
However, Python's style guide, PEP8, favors using consecutive single-line comments, like this:
# This is a multiline
# comment.
...and this is also what you'll find in many projects. Text editors usually have a shortcut to do this easily.