After reading the other answers here I came up with the below, which IMHO makes it really clear it's a comment. Especially suitable for in-script usage info:
<< ////
Usage:
This script launches a spaceship to the moon. It's doing so by
leveraging the power of the Fifth Element, AKA Leeloo.
Will only work if you're Bruce Willis or a relative of Milla Jovovich.
////
As a programmer, the sequence of slashes immediately registers in my brain as a comment (even though slashes are normally used for line comments).
Of course, "////"
is just a string; the number of slashes in the prefix and the suffix must be equal.