Yes, it is. Compute the Fast Fourier Transform and analyse the result. The Fourier transform tells you which frequencies are present in the image. If there is a low amount of high frequencies, then the image is blurry.
Defining the terms 'low' and 'high' is up to you.
Edit:
As stated in the comments, if you want a single float representing the blurryness of a given image, you have to work out a suitable metric.
nikie's answer provide such a metric. Convolve the image with a Laplacian kernel:
1
1 -4 1
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And use a robust maximum metric on the output to get a number which you can use for thresholding. Try to avoid smoothing too much the images before computing the Laplacian, because you will only find out that a smoothed image is indeed blurry :-).