I came up with a totally different solution. I needed to analyse video still frames to find the sharpest one in every (X) frames. This way, I would detect motion blur and/or out of focus images.
I ended up using Canny Edge detection and I got VERY VERY good results with almost every kind of video (with nikie's method, I had problems with digitalized VHS videos and heavy interlaced videos).
I optimized the performance by setting a region of interest (ROI) on the original image.
Using EmguCV :
//Convert image using Canny
using (Image<Gray, byte> imgCanny = imgOrig.Canny(225, 175))
{
//Count the number of pixel representing an edge
int nCountCanny = imgCanny.CountNonzero()[0];
//Compute a sharpness grade:
//< 1.5 = blurred, in movement
//de 1.5 à 6 = acceptable
//> 6 =stable, sharp
double dSharpness = (nCountCanny * 1000.0 / (imgCanny.Cols * imgCanny.Rows));
}