[python] The tilde operator in Python

~ is the bitwise complement operator in python which essentially calculates -x - 1

So a table would look like

i  ~i  
0  -1
1  -2
2  -3
3  -4 
4  -5 
5  -6

So for i = 0 it would compare s[0] with s[len(s) - 1], for i = 1, s[1] with s[len(s) - 2].

As for your other question, this can be useful for a range of bitwise hacks.