It will impact your script if you work with multi-byte text that you substring from. If this is the case, I higly recommend enabling mb_* functions in your php.ini or do this ini_set("mbstring.func_overload", 2);
$string = "'test1', 'test2', 'test3',";_x000D_
echo mb_substr($string, 0, -1);
_x000D_