I'm using THUNDERBIRD as MUA and I have same issues. I solved adding the IP address of my home PC on mynetworks parameter on main.cf
mynetworks = 127.0.0.0/8 [::ffff:127.0.0.0]/104 [::1]/128 MyIpAddress
P.S. I don't have a static ip for my home PC so when my ISP change it I ave to adjust every time.