You do not need regular expressions to check if a substring exists in a string.
line = 'This,is,a,sample,string'
result = bool('sample' in line) # returns True
If you want to know if a string contains a pattern then you should use re.search
line = 'This,is,a,sample,string'
result = re.search(r'sample', line) # finds 'sample'
This is best used with pattern matching, for example:
line = 'my name is bob'
result = re.search(r'my name is (\S+)', line) # finds 'bob'