SyntaxFix
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You can do:
x[, 1:2][is.na(x[, 1:2])] <- 0
or better (IMHO), use the variable names:
x[c("a", "b")][is.na(x[c("a", "b")])] <- 0
In both cases, 1:2 or c("a", "b") can be replaced by a pre-defined vector.
1:2
c("a", "b")