For a data.table, assigning the column to NULL removes it:
DT[,c("col1", "col1", "col2", "col2")] <- NULL
^
|---- Notice the extra comma if DT is a data.table
... which is the equivalent of:
DT$col1 <- NULL
DT$col2 <- NULL
DT$col3 <- NULL
DT$col4 <- NULL
The equivalent for a data.frame is:
DF[c("col1", "col1", "col2", "col2")] <- NULL
^
|---- Notice the missing comma if DF is a data.frame
Q. Why is there a comma in the version for data.table, and no comma in the version for data.frame?
A. As data.frames are stored as a list of columns, you can skip the comma. You could also add it in, however then you will need to assign them to a list of NULL
s, DF[, c("col1", "col2", "col3")] <- list(NULL)
.