@jeremiahbuddha mentioned that apply works on row/columns, while applymap works element-wise. But it seems you can still use apply for element-wise computation....
frame.apply(np.sqrt)
Out[102]:
b d e
Utah NaN 1.435159 NaN
Ohio 1.098164 0.510594 0.729748
Texas NaN 0.456436 0.697337
Oregon 0.359079 NaN NaN
frame.applymap(np.sqrt)
Out[103]:
b d e
Utah NaN 1.435159 NaN
Ohio 1.098164 0.510594 0.729748
Texas NaN 0.456436 0.697337
Oregon 0.359079 NaN NaN